Завідувачка лабораторії докторка хімічних наук Колодяжна Анастасія Олегівна
Основні наукові напрями лабораторії:
Chemistry of phosphorus iodides;
Asymmetric synthesis of organophosphorus compounds;
Synthesis of phosphorus analogues of natural compounds, potential biologically active compounds.
Number of Published Works : Over 450 Scientific Articles, of which more than 20 reviews and 30 patents. Knowledge of foreign languages: English, French, Russian
More Information
Member of the Scientific Council of the IBONH NAS of Ukraine;
Member of the Specialized Scientific Council of the IBONH NAS of Ukraine for the protection of PhD and Doctoral Theses;
Member of the Editorial Board of Ukrainica Bioorganica Acta;
Member of the Editorial Board of the US-based international journal Phosphorus, Sulfur, Silicon and Related Elements.
Scientific directions of the Department:
The department is engaged in the development of methods of synthesis of potential biologically active compounds of natural origin, the development of new organophosphorus reagents, new reagents and methods of asymmetric synthesis of organophosphorus compounds, chemo- and biocatalysts.
Advanced research and development:
The concept of multiple asymmetric induction as a highly efficient method of increasing the stereoselectivity of reactions and synthesis of optically pure organophosphorus compounds has been developed.
Development of methods of asymmetric synthesis of physiologically active organophosphorus compounds.
A fundamentally new method for the asymmetric synthesis of enantiomerically pure phosphines and aminophosphines has been developed using nucleophilic substitution in a phosphorus atom in the presence of bases. for asymmetric recovery and ketophosphonates on the basis of soda and tartaric acid borohydride.
Development of methods for asymmetric synthesis of C-P isosteric analogs carbohydratphosohates of natural origin (glucosephosphonates, galaktozophosphonates et al.).
Development of methods of asymmetric synthesis of hydroxyphosphonates, aminophosphonic acids: carnitine, gamma-amino-beta-hydroxybutyric acid, isostatic, etc.
Asymmetric synthesis of organophosphorus analogues of taxol,
Development of methods of asymmetric synthesis of bis-bis. Synthesis of phosphorus analogues of indoprofen, isoindolinone-1-one, epoxyisoindolinone.
Department achievements:
During the department's existence, two monographs were published, as well as several chapters and chapters in monographs published abroad, 10 reviews in international journals, more than 400 articles, 200 of which were overseas and 7 PhD theses were defended. The achievements of the department have been regularly reported at international conferences on organophosphorus chemistry and national conferences
Researches performed:
The department's research is aimed at developing preparative methods for the synthesis of potential organophosphorus biologically active compounds based on the original reagents created by the department's staff. This approach makes it possible to synthesize specific derivatives of bioactive organophosphorus compounds that are difficult or impossible to synthesize in other ways.
The search for bioactive drugs among synthesized organophosphorus compounds is carried out as employees of other departments of biological direction of the Institute of Bioorganic Chemistry.
International relations
Kolodyazhnyj Oleg Ivanovich is a member of the editorial board of the international journal Phosphorus, Sulfur, Silicon and Related Elements, published in the USA.
Recent most important publications:
1. Kolodiazhnyi O.I Phosphorus Ylides. Chemistry and Application in Organic Synthesis J. Wiley-VCH. Weinheim-New York-Chichester. 1999, P.1-565 (monograph)
2. Колодяжный О.И. Химия илидов фосфора Киев: “Наукова думка”, 1994. C.1-560 ((монографія).
3. Kolodiazhnyi O.I. New achievements in asymmetric synthesis of organophosphorus compounds.advances of asymmetric synthesis (Eds Alfred Hassner). JAI Press Inc. Stamford-London 1998. Vol. 3,P. 273-323 (chapter in monograph)
4. Kolodiazhnyi O. I. Tetrahedron: Asymmetry, report No 85 Asymmetric synthesis of hydroxyphosphonates Tetrahedron: Asymmetry 2005, Vol. 16 P. 3295-3340 (review)
5. Kolodiazhnyi O. I. Tetrahedron, report No 646 Multiple stereoselectivity and its application in organic synthesis Tetrahedron 2003 Vol.59 P. 5953-6018 (review)
6. Колодяжный О И Хиральные гидроксифосфонаты: синтез, конфигурация, биологические свойства. Успехи химии 2006, T. 75, вып 3 С 254-282 (огляд)
7. Guliaiko I. V., Kolodiazhnyi O. I. Asymmetric Syntheses of New Phosphonotaxoids Phosphorus, Sulfur, and Silicon, 2008, Vol 183, P. 677-678,
8. Nesterov V. V.; Kolodiazhnyi O. I. New Method for the Asymmetric Reduction of Ketophosphonates Phosphorus, Sulfur, and Silicon, 2008, Vol. 183, P. 687-688,
9. Kolodiazhnyi, I. V. Guliayko, E. V. Gryshkun, A. O. Kolodiazhna, V. V. Nesterov, and G. O. Kachkovskyi New Methods and Strategies for Asymmetric Synthesis of Organophosphorus Compounds O. I. Phosphorus, Sulfur, and Silicon, 2008, Vol. 183, P. 393-398,
10. Kachkovskyi G. O., Kolodiazhnyi O. I. Synthesis of Phosphonic Acids Possessing Isoindolin-1-one Moiety: Unexpected Acid-Catalyzed C-P-Bond Cleavage Phosphorus, Sulfur, and Silicon, 2009, Vol. 184, P. 890-907,
11. Guliaiko I., Nesterov V., Sheiko S., Kolodiazhnyi O. I., Freytag M., Jones P. G., Schmutzler R. Synthesis of Optically Active Hydroxyphosphonates Heteroatom Chemistry 2008, Vol 19, N 2,
12. Nesterov V. V., Kolodiazhnyi O. I. Efficient method for the asymmetric reduction of and ketophosphonates Tetrahedron 2007, Vol. 63 P. 6720-6731
13. Kachkovskyi G. O., Kolodiazhnyi O. I. Acylaminophosphonates possessing epoxyisoindolone moiety Tetrahedron 2007, Vol. 63 P. 12576-12582
14. Nesterov V. V., Kolodiazhnyi O. I. Di(1R,2S,5R)-menthyl 2-Hydroxy-3-chloropropylphosphonate as a Useful Chiral Synthon for the Preparation of Enantiomerically Pure Phosphonic Acids Preparation of Enaintiometricaly Pure Phosphonic Acids SYNLETT 2007, No. 15, pp 2400-2404
15. Nesterov V. V., Kolodiazhnyi O. I. New method for the asymmetric hydroboration of ketophosphonates and the synthesis of phospho-carnitine Tetrahedron: Asymmetry 2006, Vol. 17, P. 1023-1026
16. Nesterov V. V., Kolodyazhnyi O. I. Enantioselective Reduction of Ketophosphonates Using Chiral Acid Adducts with Sodium Borohydride Rus. J. Gen. Chem., 2006, Vol. 76, No. 7, pp. 1022-1030.
17. Kolodiazhna A. O., Kukhar V. P., Chernega A. N., Kolodiazhnyi O. I. Double and triple asymmetric induction in phosphaaldol reactions Tetrahedron: Asymmetry 2004, Vol. 15, P.1961-1963
18. Kolodiazhnyi O. I., Gryshkun E. V., Andrushko N. V., Freytag M., Jones P. G., Schmutzler R. Asymmetric synthesis of chiral N-(1-methylbenzyl)aminophosphines Tetrahedron: Asymmetry 2003, Vol. 14, P.181-183
19. Kolodiazhna A. O., Guliaiko I.V., Kolodiazhnyi O. I.. Diasteroselective Addition of Mono and Bis-Silylphosphines to Chiral Aldehydes Phosphorus, Sulfur and Silicon, 2005, V. 180, N 10, P: 2335 – 2346
20. Kolodiazhnyi, O.I. Guliaiko, I.V. Kolodiazhna A.O. Highly stereoselective addition of silylphosphines to chiral aldehydes. Tetrahedron Letters, 2004, 45, N 37, 6955-6957
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вул Академіка Кухаря, 1,
Інститут біоорганічної хімії НАН України.
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