V.P. Kukhar Institute
of Bioorganic
chemistry and
Petrochemistry
NAS of Ukraine

2019

• Joint project “Proteins that bind salicylic acid in plants: study by methods of biochemistry and molecular dynamics” (France, 2019-2020). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “Phosphatidylinositols: hidden mechanisms of immune responses in plants” (Czech Republic, 2019). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “New low-molecular-weight bioregulators as effective agents against multi-resistant clinical isolates” (Germany, 2019-2020). Head: L.O. Metelytsia, Ph.D.
• Synthesis and properties of new oxazole and oxazolopyrimidine derivatives. Development of new potential antitumor agents based on [1,3]oxazolo[5,4-d]pyrimidines. Cooperation agreement with Tallinn University of Technology (Estonia, 2019–2024).

2018

• Study of chemically modified three-dimensional organic matrices (Germany, 2018–2022). Cooperation agreement with the Institute of Electronics and Sensor Materials at the Technical University of Mining and Geology in Freiberg (Germany, 2018–2023).
• Synthesis and study of the antiviral activity of nitrogenous heterocyclic compounds. NIAID non-clinical testing agreement with the National Institute of Allergy and Infectious Diseases (USA, 2018–2023).
• Creation of new plant growth regulators to enhance the immune properties of plants against abiotic and biotic stress factors with a view to their application in agricultural biotechnology (United Kingdom, 2018). Head: V.A. Tsygankova, Doctor of Biological Sciences.
• Inverted microemulsions to increase the extraction of hydrocarbon raw materials. Agreement on scientific cooperation with Oil Smart Technologies (Kazakhstan, 2018–2021).

2017

• Development of new nanostructured conjugated polymers as sorbents for the removal of harmful substances from water. Memorandum of Understanding with Clemson University (USA, 2017–2019).
• Joint project “Phospholipid metabolism as a new component of phytohormone signaling pathways” (Czech Republic, 2017-2019). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.

2016

• Joint project “Lipid signaling and hormonal regulation: cross-interaction in plants” (France, 2016-2018). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “The role of phosphatidylinositol-4-kinases in the formation of the root system of plants and in response to hormones” (Czech Republic, 2016-2017). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.

2015

• Joint project “Development of a super-selective adsorbent against SDOR” (USA, NATO Science for Peace and Security Program, 2014-2017). Head: L.V. Golovko, PhD (2014-2016). Head: V.A. Povazhny, PhD (2016-2017).

2014

• Joint project “Evaluation of the role of the phospholipase C family in the adaptation of plant metabolism to stressful conditions using a transgenic Arabidopsis model” (Czech Republic, 2014-2016). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “Investigation of the involvement of phosphatidylinositol kinases in hormonal and stress signaling” (France, 2014-2017). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “Development of furin inhibitors” (USA, 2014-2017). Head: T.V. Osadchuk, Ph.D.
• Joint project “Modification of cellulose surfaces with flavonoids: development of methods for introducing antibacterial and antifungal properties” (Sweden, 2014). Head: T.V. Osadchuk, Ph.D.
• Joint project “Investigation of new substances for anticancer activity” (USA, 2014-2019). Head of the project: M.S. Frasynyuk, Ph.D. in Chemistry.

2013

• Joint project “Investigation of phase transitions of enantiomer mixtures, in particular, sublimation of mixtures of natural amino acids” (France, 2013-2014). Head: Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor V.P. Kukhar.
• Non-clinical testing by NIAID at the US National Institutes of Health (USA, 2013-2018). Head: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor Brovarets V.S.
• Joint project “Enterolignans and their functionalized analogues: synthesis and application” (France, 2013-2014). Head: Fedoryak O.D., Candidate of Chemical Sciences.

2012

• Joint project “Modeling and experimental studies of liposomes and new synthetic antioxidants” (Japan, 2012-2016). Head of the project: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor A.I. Vovk
• Joint project “Ecotoxicity of metal nanoparticles and metal oxides: experimental studies and modeling” (Netherlands, NATO Science for Peace and Security Program, 2012-2015). Head: L.O. Metelytsia, Ph.D.
• Joint project “Synthesis of Ionenes” (USA, 2012). Head: S.P. Rogalsky, PhD in Chemistry.
Joint project “Electrochemical synthesis for photovoltaic applications of hybrid semiconductor structures” (Japan, 2012).
• Head: O.A. Pud, Doctor of Chemical Sciences, Professor.

2011

• Joint project “Molecular features of plant responses to abiotic and biotic stresses” (Czech Republic, 2011-2013). Head: V.S. Kravets, Doctor of Biological Sciences, Professor.
• Joint project “iPRIOR – an online platform for predicting toxicity and prioritizing chemical compounds for the discovery of new drugs” (Germany, 2011-2013). Head: V.V. Prokopenko, Candidate of Biological Sciences.
• Joint project “Synthesis and study of organic molecules capable of enhancing the efficiency of somatic cell reprogramming” (Mexico, 2011-2012). Head: Fedoryak O.D., Candidate of Chemical Sciences.
• Joint project “Hybrid organic-inorganic nanocomposites for sensory applications” (France, 2011-2016). Head of the project: O.A. Pud, Doctor of Chemical Sciences, Professor.

2010

• Non-clinical testing of NCI at the National Cancer Institute of the United States (USA, 2010-2017). Head: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Prof. Brovarets V.S.
• Joint project “Synthesis and evaluation of metal-immobilized porous mineral oxides as sorbents for deep desulfurization of transport fuels” (USA, 2010-2011). Head: V.P. Kiselov, Candidate of Technical Sciences.
• STCU project “Search for effective inhibitors of protein tyrosine phosphatases using nanochemical approaches and evaluation of their biological efficacy in silico” (2010-2012). Head: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor A.I. Vovk
• Joint project “Development of selective composite membranes based on porous polymer structures and ionic liquids” (France, 2010-2011). Head: S.P. Rogalsky, Ph.D.
• Joint project “Hybrid composites of the core-shell type of electrically conductive polymer and their application” (USA, 2010-2012). Head of the project: Doctor of Chemical Sciences, Professor O.A. Pud.

2009

• Joint project “Study of the structure, reactivity and bioregulatory properties of fluorinated derivatives of phosphonic and bisphosphonic acids” (France, 2009-2011). Head: Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Prof. V.P. Kukhar. Joint project “Highly efficient adsorbents for CO2 capture in combustion products” (USA, 2009-2011). Head: Candidate of Chemical Sciences L.V. Golovko.

• Joint project “New transformations of fluorine-containing ketones with organophosphorus compounds” (Germany, 2009-2011). Head: Sorochinsky O.E., PhD in Chemistry.
• Joint project “New synthetic routes to polyfluoroalkyl-containing amino- and/or hydroxy acids with potential biological activity” (Germany, 2009-2011). Head: I.I. Gerus, Ph.D.
• Joint project “Study of the reactions of phosphites and fluorinated unsaturated ketones” (Germany, 2009-2011). Head: Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor V.P. Kukhar.
• Joint project “Molecular basis of plant responses to abiotic stresses” (China, 2009-2010). Head: V.S. Kravets, Doctor of Biological Sciences, Professor.
• Joint project “Synthesis of new fluorinated mimetics of natural biologically active compounds” (Germany, 2009-2011). Head: Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor V.P. Kukhar.
• Joint project “Hybrid nanocomposites of silicon carbide with poly aniline” (France, 2009-2010). Head: Doctor of Chemical Sciences, Professor O.A. Pud.
• Joint project “Core-shell polymer composites of polyvinylidene fluoride-polyaniline (polytrimethylthiophene) and their applications” (USA, 2009). Head: O.A. Pud, Doctor of Chemical Sciences, Professor.

2008

• Joint project “New functional materials based on nano- and microcomposites” (Canada, 2008-2011). Head: Candidate of Chemical Sciences, Sheldyko Ye.V.
• Joint project “The role of phospholipases C and D in plant responses to stress” (Czech Republic, 2008-2010). Head: Prof. V.S. Kravets, Doctor of Biological Sciences.
• Joint project “Expert system for predicting the activity of compounds interacting with cytochrome” (Germany, 2008-2010). Head: V.V. Kovalishyn, PhD in Biology.
• Joint project “Synthesis of fluorinated nitrogen-containing heterocyclic compounds” (USA, 2008-2009). Head: Prof. B.S. Drach, Doctor of Chemical Sciences.
• Joint project “Molecular basis of plant responses to abiotic and biotic stresses” (Czech Republic, 2008-2010). Head: V.S. Kravets, Doctor of Biological Sciences, Professor.

2007

• Joint project “Fluorinated phosphonic acid derivatives: synthesis and application in bio- and medical chemistry” (Germany, 2007-2010). Head: Prof. Romanenko V.D., Doctor of Chemical Sciences.
• Joint project “Development of ADME/T methods using Associative Neural Networks: new self-learning software for reliable ADME/T predictions” (Germany, 2007-2010). Head of the project: V.V. Prokopenko, Candidate of Biological Sciences.
• Joint project “New derivatives of difluoromethylphosphonates and phosphinates” (Germany, 2007-2009). Head: Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor V.P. Kukhar
• Joint project “Internal modification of polycarbonates” (USA, 2007-2009). Head: S.P. Rogalsky, PhD in Chemistry.
• Joint project “Synthesis of guanidine derivatives” (USA, 2007). Head: S.P. Rogalsky, PhD in Chemistry.

2006

• Joint project “From Design to Synthesis of New Anti-Tuberculosis Agents” (Portugal, 2006-2010). Head: V.V. Prokopenko, PhD in Biology.
• Joint project “Development of synthetic approaches to new types of azole and azine derivatives – potential bioregulators” (USA, 2006-2009). Head: B.S. Drach, Doctor of Chemical Sciences, Professor.
• Joint project “Hybrid organic-inorganic heterostructures for photovoltaic devices” (Germany, Sweden, USA, 2006-2008). Head of the project: Prof. O.A. Pud, Doctor of Chemical Sciences.
• STCU project “Development of a reactor for the production of synthetic fuel on composite proton-conducting membranes” (2006-2009). Head: V.A. Bortyshevsky, Candidate of Chemical Sciences.
• STCU project “Internal modification of polycarbonates” (2006-2009). Head: S.P. Rogalsky, PhD in Chemistry.
• Joint project “Study of organophosphorus compounds by methods of theoretical chemistry and photoelectron spectroscopy” (France, 2006). Head: V.D. Romanenko, Doctor of Chemical Sciences, Professor.
• Joint project “Research on the synthesis of fluorine-containing aminophosphoric acids” (Germany, 2006). Head: Sorochinsky O.E., Ph.D.

2005

• Joint project “Interphase effects of electrically conductive charged polymers on the electronic and optical properties of host-guest composites of polymers with nanocrystals” (France, 2005-2006). Head: Prof. O.A. Pud, Doctor of Chemical Sciences.

2004

• Joint project “New anti-friction and anti-wear coatings for operation in extreme conditions” (Italy, Germany, 2004-2007). Head: Yevhen Sheldyko, PhD in Chemistry.
• Joint project “Oxygen stress. Mechanism of action of antioxidants and radioprotectors” (USA, 2004-2007). Head: G.S. Shapoval, Doctor of Chemical Sciences, Professor.
• Joint project “Virtual Laboratory of Computational Chemistry” (Sweden, Germany, Great Britain, 2004). Head: V. Yu. Tanchuk, Ph.D.
• Joint project “Electrically Conductive Polymer Composites” (France, 2004). Head: Prof. Shapoval G.S., Doctor of Chemical Sciences.
• Joint project “New plant protection products of natural origin: isolation, synthesis and application on major greenhouse and grape pests” (Greece, 2004-2005). Head: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor O.I. Kolodyazhny.

2002

• Joint project “The role of phospholipases in the action of cytokinins” (Czech Republic, Germany, 2002-2005). Head: V.S. Kravets, Doctor of Biological Sciences, Professor. 2001
• Joint project “Polymer nanomaterials: conventional and smart gels incorporating physical networks of polyelectrolytes in interaction with surfactants, proteins, and organic molecules” (Germany, Belgium, 2001-2005). Head: T.O. Gushcha, Candidate of Physical and Mathematical Sciences.
• Joint project “Directed synthesis and use of adamantane derivatives, framework and polycyclic compounds, triterpenes, subarin, and talic acids for the formation of highly effective anti-wear films on friction surfaces in high-temperature environments”
(USA, 2001-2003). Head: L.V. Golovko, PhD in Chemistry. Joint project “Synthesis and study of multicomponent oxide systems as promising catalysts and adsorbents” (Poland, 2001-2003).
• Head: L.K. Patryliak, Doctor of Chemical Sciences.
• Joint project “Development of the synthesis of latanoprost” (Israel, 2001-2002). Head: V.P. Kukhar, Academician of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor.
• Joint project “Molecular dynamics of proteins in solution. Relaxation studies of human serum albumin in a wide frequency range” (Germany, 2001). Head: T.O. Gushcha, Candidate of Physical and Mathematical Sciences.
• Joint project “Asymmetric synthesis” (Germany, 2001). Head: Corresponding Member of the National Academy of Sciences of Ukraine, Doctor of Chemical Sciences, Professor Kolodyazhny O.I.

2000

• Joint project “Synthesis of dendrimeric macromolecules and their modification with fluorinated substituents” (USA, 2000-2001). Head: Sheldyko E.V., PhD in Chemistry.