Andrii Ivanovych Vovk

Corresponding Member of the NAS of Ukraine, Doctor of Chemical Sciences, Professor.

Advisor to the Directorate, Head of the Department of Mechanisms of Bioorganic Reactions.

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1. Compulsory educational discipline ОНД 1.03 “Organizational Principles and Effectiveness of Scientific Research in Chemistry. Pedagogy of Higher Education.”

Specialty E3 Chemistry

First year, semesters 1, 2

Total course load – 4 ECTS credits (120 hours). Instructor’s workload – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 2.01 “Molecular Mechanisms in Bioorganic Chemistry.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity include the study of the mechanisms of model reactions and the bioactivity mechanisms of natural and synthetic organic compounds, the design and synthesis of potentially bioactive organic molecules, establishing the relationship between their structure and activity, and predicting bioactivity using computer modeling methods. The objects of research are natural and synthetic heterocyclic and organophosphorus compounds, as well as therapeutically important hydrolases, transferases, oxidoreductases, and other protein structures as potential targets. Recent work has focused on studying the properties of bioactive structural analogues of vitamin B1, and on the search for, design, synthesis, and study of inhibitors of non-specific alkaline phosphatases, protein tyrosine phosphatases, cholinesterases, glutathione S-transferases, xanthine oxidase, α-glucosidase, and other enzymes. Research on antioxidants and spin probes continues. Alongside in vitro experimental approaches, the research employs molecular docking, molecular dynamics, and QSAR methods.

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Research work

Stepan Hryhorovych Pilyo

Doctor of Chemical Sciences, Senior Researcher.

Head of the Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases.

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Compulsory educational discipline ОНД 2.01 “Fundamentals of Bioorganic Chemistry.”

Specialty E3 Chemistry

Second year, semesters 3, 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity include the development of preparative methods for the synthesis of potentially bioactive substances of a heterocyclic nature with the aim of finding effective antitumor, antiviral, vasodilator agents, enzyme inhibitors, pesticides, plant growth regulators, and others. To achieve this goal, S.H. Pilyo uses original acyclic reagents for the synthesis of five- and six-membered nitrogen-containing heterocycles and their fused derivatives, which contain various nitrogen-, sulfur-, and phosphorus-containing pharmacophoric groups at different positions of the heterocyclic system. A promising area of Stepan Pilyo’s work is the search for new effective and environmentally safe plant growth regulators based on synthetic five- and six-membered heterocyclic compounds, with a view to their practical implementation in agriculture to improve the growth and development of commercially important crops and increase their yield.

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Research work

Oleh Borysovych Smoliy

Doctor of Chemical Sciences, Professor.

Head of the Department of Chemistry of Natural Compounds.

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Elective educational discipline ДВА 1.02 “Postgraduate Research Seminar.”

Specialty E3 Chemistry

Second year, semester 3

Total course load – 3 ECTS credits (90 hours).

The main areas of scientific activity include: the search for approaches to the synthesis of potential biologically active substances based on structural analogues of natural compounds; the development of preparative methods for introducing pharmacophoric groups at appropriate positions of cyclic systems to increase biological activity; and establishing the influence of the structural features of the obtained compounds on their biological activity.

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Research work

Liubov Kazymyrivna Patrylyak

Doctor of Chemical Sciences, Professor.

Head of the Department of Catalytic Synthesis.

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1. Compulsory educational discipline ОНД 2.02 “General Issues of Petrochemistry and Coal Chemistry.”

Specialty E3 Chemistry

Second year, semesters 3, 4

Total course load – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 2.07 “Catalytic Processes of Petroleum Refining.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

3. Elective educational discipline ДВА 2.10 “Surfactants – Synthesis, Properties, Application.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity: acid-base catalysis of hydrocarbon conversion; new phenomena in the field of heterogeneous catalysis and the nature of the catalytic activity of zeolite catalysts; study of the adsorption and acid-base properties of heterogeneous catalysts; study of the patterns of carbonium-ion reactions and the effectiveness of the synthesized catalysts in model reactions and on real hydrocarbon mixtures; synthesis of micro-mesoporous carbon sorbents and catalysts; production of biofuels and bio-lubricant materials based on renewable raw materials – oils of various origin and ethyl/propyl/butyl alcohols; development and synthesis of environmentally safe surfactants, technological systems, and materials; conversion of simple carbohydrates (glucose, fructose) into platform chemicals (5-hydroxymethylfurfural, levulinic acid, etc.); oleochemical syntheses based on fatty acid epoxides.

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Research work

Ihor Ivanovych Herus

Doctor of Chemical Sciences, Senior Researcher.

Head of the Department of Fine Organic Synthesis.

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1. Compulsory educational discipline ОНД 2.03 “Physicochemical Methods for Studying Molecular Structure.”

Specialty E3 Chemistry

Second year, semester 3

Total course load – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 2.02 “Modern Methods of Organic Synthesis of Bioactive Compounds.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours). Instructor’s workload – 2 ECTS credits (60 hours).

The main scientific area of activity is the development of methods for the targeted synthesis of phosphorus- and fluorine-containing isoelectronic and bioisosteric structural analogues of natural compounds. I.I. Herus has established that the introduction of fluorine atoms into the structure of molecules does not lead to significant changes in the spatial structure of organic molecules, since the sizes of hydrogen and fluorine atoms are very close, but the special electronic properties of the fluorine atom and fluorine-containing groups often lead to fundamental and positive changes in the chemical behavior and biological activity of compounds. Also an interesting and promising area of I.I. Herus’s work is the synthesis and study of organophosphorus molecules containing fluorine-containing fragments.

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Research work

Larysa Oleksiivna Metelytsia

Doctor of Biological Sciences, Professor,

Head of the Laboratory of Biomedical Research.

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1. Compulsory educational discipline ОНД 2.03 “Methods for Studying Bioactivity In Silico and In Vitro.”

Specialty E1 Biology and Biochemistry

Second year, semesters 3, 4

Total course load – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 1.01 “A Systematic Approach to Scientific Writing.”

E1 Biology and Biochemistry

Second year, semester 3

Total course load – 4 ECTS credits (120 hours).

3. Elective educational discipline ДВА 2.01 “Biologically Active Substances as Antimicrobial Agents.”

E1 Biology and Biochemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

4. Elective educational discipline ДВА 2.05 “Methods for Studying Bioactivity In Silico and In Vitro.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main scientific direction of research is the study, using in silico, in vitro, and in vivo methods, of new low-molecular-weight compounds as promising bioregulators with a broad spectrum of action. L.O. Metelytsia is a specialist in chemoinformatics and medical/biological chemistry, who successfully uses virtual screening based on QSAR/QSTR approaches to predict the properties of new biologically active compounds. Based on the analysis of established patterns, a number of heterocyclic compounds with high antioxidant potential of antimicrobial, antiviral, and anticancer action are identified. Particular attention in L.O. Metelytsia’s research is paid to in vivo studies of toxicity, including the ecotoxicity of the most promising compounds.

Main publications on the topic

Research work

Oleksandr Volodymyrovych Holovchenko

Doctor of Chemical Sciences, Senior Researcher.

Acting Deputy Director for Research, Senior Researcher of the Department of Bioactive Nitrogen-Containing Heterocyclic Bases.

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Elective educational discipline ДВА 2.02 “Modern Methods of Organic Synthesis of Bioactive Compounds.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours). Instructor’s workload – 2 ECTS credits (60 hours).

The main areas of scientific activity include the development of preparative methods for the synthesis of phosphorus-containing heterocyclic systems and the study of the synthesized substances for antibacterial, antiviral, antitumor, and other types of biological activity.

Main publications on the topic

Research work

Anastasiia Olehivna Kolodiazhna

Doctor of Chemical Sciences, Senior Researcher.

Head of the Laboratory of Synthesis of Physiologically Active Phosphorus Compounds.

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Elective educational discipline ДВА 2.03 “Bioactive Organoelement Compounds.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity concern the chemistry of phosphorus ylides, the asymmetric synthesis of organic, organoelement, and organophosphorus compounds, the synthesis of phosphorus analogues of natural compounds, and potential biologically active compounds. A.O. Kolodiazhna’s research is aimed at developing preparative methods for the synthesis of organic, organoelement, and organophosphorus compounds with potential biological activity, as well as establishing the main patterns of their chemical behavior and identifying the possibilities of using these chiral synthons in the synthesis of enantiomerically pure bioregulators.

Main publications on the topic

Research work

Mykhailo Serhiiovych Frasyniuk

Doctor of Chemical Sciences, Professor.

Leading Researcher of the Department of Chemistry of Natural Compounds.

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Elective educational discipline ДВА 2.04 “Fundamentals of the Chemistry of Natural Compounds.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity include: the search for and study of new approaches to the synthesis and modification of natural flavonoids and their analogues; the development of simple and effective methods for obtaining benzothiazole and benzimidazole analogues of isoflavones, 3-(2-benzazolyl)coumarins, and the study of their physicochemical properties; the use of Mannich bases of isoflavones as intermediate compounds for obtaining new oxygen-containing heterocyclic systems based on the chromone core.

Main publications on the topic

Research work

Vitalii Oleksandrovych Yevdokymenko

Ph.D. (Chem.), Senior Researcher.

Head of the Department of Organic and Petrochemical Synthesis.

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Elective educational discipline ДВА 2.08 “Alternative Raw Materials for Organic and Petrochemical Synthesis.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity concern the processing of carbon oxides on industrial catalysts to obtain alcohols and motor fuel components; the study of scientific and technical aspects of the key stages of the technological scheme for processing plant biomass and anthropogenic waste to obtain chemical reagents, both as base products and as precursors for organic synthesis products; the development of organo-mineral fertilizers and primers from anthropogenic and agricultural waste; and the synthesis and study of polyfunctional modifying additives based on plant and petrochemical raw materials for industrial polymers.

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Research work

Oleksandr Arkadiiovych Pud

Doctor of Chemical Sciences, Professor,

Head of the Department of Chemistry of Functional Materials.

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Elective educational discipline ДВА 2.09 “Monomers and Polymers in Organic and Petrochemical Synthesis.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main scientific areas of activity are related to the synthesis and study of the formation features, properties, structure, morphology, and functioning of “smart” hybrid (nano)composites of electrically conductive and biocompatible conjugated polymers/biopolymers with polymers of a different nature, inorganic nanoparticles (semiconductor, dielectric, magnetic, etc.), or with carbon materials (carbon nanotubes, carbon fibers). O.A. Pud studies the efficiency of synthesized/formed nanocomposites of electrically conductive and biocompatible conjugated polymers as sensor, electrically conductive, thermosensitive, and photoactive materials, carriers of medical and diagnostic agents in living organisms, for protection against electromagnetic radiation and static electricity, sorbents of heavy metal cations and pollutants in natural waters, etc. The developed materials can also be used in photovoltaic and electrochromic devices, for protecting metals from corrosion, etc.

Main publications on the topic

Research work

Olha Valentynivna Shablykina

Ph.D. (Chem.).

Senior Researcher of the Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases.

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Elective educational discipline ДВА 2.06 “Chemistry of Alkaloids.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity: organic chemistry of aromatic and heterocyclic compounds, chemistry of alkaloids, current aspects of medicinal chemistry, and combinatorial chemistry.

Main publications on the topic

Research work

Viktoriia Anatoliivna Tsygankova

Doctor of Biological Sciences.

Leading Researcher of the Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases.

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1. Compulsory educational discipline ОНД 1.03 “Methodology and Organization of Scientific Research in Biology and Biochemistry.”

Specialty E1 Biology and Biochemistry

First year, semesters 1, 2

Total course load – 4 ECTS credits (120 hours).

2. Compulsory educational discipline ОНД 2.01 “Bioorganic Chemistry.”

Specialty E1 Biology and Biochemistry

Second year, semesters 3, 4

Total course load – 4 ECTS credits (120 hours).

3. Elective educational discipline ДВА 2.03 “Low-Molecular-Weight Plant Bioregulators.”

Specialty E1 Biology and Biochemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main areas of scientific activity concern the creation of new environmentally safe plant growth regulators of synthetic and natural origin, as well as the study of the physiological and molecular-genetic aspects of their action on accelerating the growth and development of agricultural and medicinal plants, increasing the yield and resistance of agricultural crops to pathogenic and parasitic organisms (bacteria, fungi, nematodes, and insect pests), as well as to environmental stress factors (drought, cold, elevated temperatures, soil pollution, etc.).

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Research work

Mykhailo Viktorovych Derevianchuk

Ph.D. (Biol.).

Head of the Laboratory of Molecular Mechanisms of Cell Metabolism Regulation.

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1. Elective educational discipline ДВА 1.02 “Organization and Preparation of a Dissertation.”

E1 Biology and Biochemistry

Second year, semester 3

Total course load – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 2.02 “Signaling Systems of Cells at Different Levels of Organization.”

E1 Biology and Biochemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

3. Elective educational discipline ДВА 2.05 “Fundamentals of Bioenergetics.”

Specialty E3 Chemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main scientific direction of research is the study of the molecular mechanisms of cell metabolism regulation, in particular hormonal and stress signaling. The objects of study are the model plant system Arabidopsis thaliana and a number of cultivated plants (rapeseed, barley, soybean). The laboratory conducts current research to elucidate the mechanisms of the influence of the hormones brassinosteroids and cytokinins on the regulation of key metabolic links – from the early processes of signal reception and the formation of signaling messengers, to determining changes in the functioning of key cell homeostasis systems, in particular the functioning of the mitochondrial respiratory chain. Recently, M.V. Derevianchuk’s work has focused on studying the cell’s adaptive mechanisms to the action of toxic metals, in particular zinc and copper. Pollution with heavy metals is one of the challenges of martial law. The researcher conducts promising studies on the role of cytokinins in increasing plant resistance to stress conditions caused by toxic metals, in particular by programming the adaptive hormonal profile of plants.

Main publications on the topic

Research work

Diana Mykolaivna Hodyna

Ph.D. (Biol.).

Senior Researcher of the Laboratory of Biomedical Research.

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1. Compulsory educational discipline ОНД 2.02 “Biochemistry of the Mechanisms of Regulation of Biological Systems.”

Specialty E1 Biology and Biochemistry

Second year, semesters 3, 4

Total course load – 4 ECTS credits (120 hours).

2. Elective educational discipline ДВА 2.04 “Bioinformatics in Biochemical Research.”

E1 Biology and Biochemistry

Second year, semester 4

Total course load – 4 ECTS credits (120 hours).

The main scientific direction of research is the study, using in silico, in vitro, and in vivo methods, of new low-molecular-weight compounds as promising bioregulators with a broad spectrum of action.

Main publications on the topic

Research work

1. Velihina Y., Scattolin T., Bondar D., Pil’o S., Obernikhina N., Kachkovskyi O., Semenyuta I., Caligiuri I., Rizzolio F., Brovarets V., Karpichev Y., Nolan S.P. Synthesis, in silico and in vitro evaluation of novel oxazolopyrimidines as promising anticancer agents. Helv. Chim. Acta. 2020. Vol. 103, N 2. e2000169. https://doi.org/10.1002/hlca.202000169 [Q2]

2. Semenyuta I., Kovalishyn V., Tanchuk V., Pilyo S., Zyabrev V., Blagodatnyy V., Trokhimenko O., Brovarets V., Metelytsia L. 1,3-Oxazole derivatives as potential anticancer agents: Computer modeling and experimental study. Comput Biol Chem. 2016. Vol. 65. P. 8-15. https://doi.org/10.1016/j.compbiolchem.2016.09.012 [Q3]

3. Severin O., Obernikhina N., Pilyo S., Kachaeva M., Kachkovsky O., Kozachenko O., Brovarets V., Bodachivskyi I. A Comparative In Vitro Anticancer Evaluation and In Silico Study of New 1-(1,3-Oxazol-5-yl)piperidine-4-sulfonylamides. ChemistrySelect. 2024. Vol. 9. e202403531. https://doi.org/10.1002/slct.202403531 [Q3]

4. Циганкова В.А., Андрусевич Я.В., Штомпель О.І., Копіч В.М., Пільо С.Г., Прокопенко В.М., Головченко О.В., Корнієнко А.М., Броварець В.С. 7-Циклоамінозаміщені оксазоло[4,5-d]піримідини як регулятори росту рослин / патент України № 119425. Заявл. 30.10.2017, опубл. 10.06.2019, Бюл. № 11

1. Patrylak L.K., Yakovenko A.V., Nizhnik B.O., Pertko O.P., Povazhnyi V.A., Kamenskyh D.S., Melnychuk O.V. Natural Zeolites Modified with Silver Nanoparticles as Promising Sorbents with Antibacterial Properties. In: Fesenko, O., Yatsenko, L. (eds) Nanoelectronics, Nanooptics, Nanochemistry and Nanobiotechnology, and Their Applications. NANO 2022. Springer Proceedings in Physics. 2023. Vol. 297. P. 87–98. Springer, Cham. https://doi.org/10.1007/978-3-031-42708-4_5

2. Пертко О.П., Волошина Ю.Г., Патриляк Л.К. Спосіб одержання цеолітного каталізатора алкілування толуолу метанолом в бічний ланцюг. Пат. України на корисну модель № 140722. Заявл. 17.07.2019, опубл. 10.03.2020, Бюл. № 5

1. Vdovenko S.I., Gerus I.I., Zhuk Y.I., Kukhar V.P., Pagacz-Kostrzewa M., Wierzejewska M., Daniliuc C.G. The conformational analysis of push-pull enaminones using FTIR and NMR spectroscopy, and quantum chemical calculations. VI. β−N− Methyl-aminovinyl trifluoromethyl ketone and α−methyl−β−N− methylaminovinyl trifluoromethyl ketone. Journal of Molecular Structure. 2017. Vol. 1128. P. 741–753. https://doi.org/10.1016/j.molstruc.2016.09.049 [Q3]

2. Vdovenko S.I., Gerus I.I., Zhuk Y.I., Kukhar V.P., Röschenthaler G.-V. The conformational analysis of push–pull enaminones using Fourier transform IR and NMR spectroscopy, and quantum chemical calculations. V. α-Methyl-, fluorine-β-N,N-dimethylaminovinyl trifluoromethyl ketones. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2014. Vol. 131. P. 94–101. https://doi.org/10.1016/j.saa.2014.04.053 [Q2]

1. Kobzar O., Ocheretniuk A., Buldenko V., Babiy L., Kozachenko O., Brovarets V., Vovk A. O-Substituted N(3)-benzyl analogs of vitamin B₁ as inhibitors of acetylcholinesterase or butyrylcholinesterase. Chem. Lett. 2020. Vol. 9(1). P. 51–62. http://doi.org/10.5267/j.ccl.2019.7.002 [Q2]

2. Kobzar O., Shulha Y., Buldenko V., Cherenok S., Silenko O., Kalchenko V., Vovk A. Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids. Bioorganic & Medicinal Chemistry Letters. 2022. Vol. 77. P. 129019. https://doi.org/10.1016/j.bmcl.2022.129019 [Q2]

3. Kovalishyn V., Severin O., Kachaeva M., Kobzar O., Keith K.A., Harden E.A., Hartline C.B., James S.H., Vovk A., Brovarets V. In Silico Design and Experimental Validation of Novel Oxazole Derivatives Against Varicella zoster virus. Mol Biotechnol. 2024. Vol. 66(4). P. 707–717. doi: 10.1007/s12033-023-00670-w [Q2]

4. Buldenko V.M., Trush V.V., Kobzar O.L., Drapailo A.B., Kalchenko V.I., Vovk A.I. Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases. Bioorganic & Medicinal Chemistry Letters. 2019. Vol. 29, Issue 6. P. 797–801. https://doi.org/10.1016/j.bmcl.2019.01.026 [Q1]

5. Los O.V., Sinenko V.O., Kobzar O.L., Zhirnov V.V., Vovk A.I., Brovarets V.S. Synthesis and in vitro anticancer potential of new thiazole-containing derivatives of rhodanine. Chem Heterocycl Comp. 2023. Vol. 59(6-7). P. 484–493. https://doi.org/10.1007/s10593-023-03220-z [Q4]

6. Tanchuk V.Yu., Tanin V.O., Vovk A., Poda G. A New, Improved Hybrid Scoring Function for Molecular Docking and Scoring Based on AutoDock and AutoDock Vina. Chem. Biol. Drug Des. 2016. Vol. 87. P. 618–625. https://doi.org/10.1111/cbdd.12697 [Q3]

1. Brusnakov M.Y., Golovchenko O.V., Potikha L.M., Brovarets V.S. 1,3-Oxazoles As Precursors of Phosphorylated Amino Acids and Peptidomimetics. Ukrainica Bioorganica Acta. 2022. Vol. 17 (1). P. 72–80. https://doi.org/10.15407/bioorganica2022.01.072 (категорія Б)

2. Semenyuta I., Golovchenko O., Bahrieieva O., Vydzhak R., Zhirnov V., Brovarets V. Synthesis, Characterization, In Vitro Anticancer Evaluation, ADMET Properties, and Molecular Docking of Novel 5‐Sulfanyl Substituted (Thiazol‐4‐yl)‐Phosphonium Salts. ChemMedChem. 2024. Vol. 19. e202400205. https://doi.org/10.1002/cmdc.202400205 [Q2]

3. Brusnakov M.Y., Golovchenko O.V., Potikha L.M., Brovarets V.S. Condensed azole-based organophosphorus heterocycles. Chemistry of Heterocyclic Compounds. 2023. Vol. 59(4). P. 217–236. https://doi.org/10.1007/s10593-023-03184-0 [Q4]

4. Malets Y.S., Vashchenko B.V., Moskvina V.S., Golovchenko O.V., Brovarets V.S., Grygorenko O.O. Parent 5(7)-azachromones and their partially hydrogenated derivatives: synthesis and physicochemical properties. Chem Heterocycl Comp. 2023. Vol. 59. P. 494–499. https://doi.org/10.1007/s10593-023-03221-y [Q4]

1. Trofymchuk S., Bugera M.Y., Klipkov A.A., Razhyk B., Semenov S., Tarasenko K., Starova V.S., Zaporozhets O.A., Tananaiko O.Yu., Alekseenko A.N., Pustovit Y., Kiriakov O., Gerus I.I., Tolmachev A.A., Mykhailiuk P.K. Deoxofluorination of (Hetero) aromatic Acids. Journal of Organic Chemistry. 2020. Vol. 85(5). P. 3110–3124. https://doi.org/10.1021/acs.joc.9b03011 [Q1]

2. Homon A.A., Hryshchuk O.V., Mykhailenko O.V., Vashchenko B.V., Melnykov K.P., Michurin O.M., Daniliuc C.G., Gerus I.I., Kovtunenko V.O., Kondratov I.S., Grygorenko O.O. 4‐(Di‐/Trifluoromethyl)‐2‐heterabicyclo[2.1.1]hexanes: Advanced Fluorinated Phenyl Isosteres and Proline analogues. European Journal of Organic Chemistry. 2021. Vol. 2021(47). P. 6580–6590. https://doi.org/10.1002/ejoc.202100414 [Q2]

3. Bugera M.Y., Tarasenko K.V., Kondratov I.S., Gerus I.I., Vashchenko B.V., Ivasyshyn V.E., Grygorenko O.O. (Het) aryl Difluoromethyl‐Substituted β‐Alkoxyenones: Synthesis and Heterocyclizations. European Journal of Organic Chemistry. 2020. Vol. 2020(9). P. 1069–1077. https://doi.org/10.1002/ejoc.201901833 [Q2]

4. Homon A.A., Shynder L.V., Demchuk O.P., Hryshchuk O.V., Kondratov I.S., Gerus I.I., Grygorenko O.O. Synthesis of 1,3-bifunctional cyclobutane derivatives with α-CHF₂/CF₃ group-advanced building blocks for medicinal chemistry. Journal of Fluorine Chemistry. 2022. Vol. 263. P. 110041. https://doi.org/10.1016/j.jfluchem.2022.110041 [Q3]

1. Kolodiazhna A.O., Kolodiazhnyi O.I. Asymmetric Electrophilic Reactions in Phosphorus Chemistry. Symmetry. 2020. Vol. 12. P. 108. https://doi.org/10.3390/sym12010108 [Q2]

2. Kolodiazhna A., Prysiazhnuk D.,  Kolodiazhnyi O. Enzymatic resolution of heterocyclic intermediates for biologically active compound preparation. Phosphorus, Sulfur, and Silicon and the Related Elements. 2024. Vol. 199 (10–12). P. 843–855. https://doi.org/10.1080/10426507.2024.2367033 [Q4]

3. Kolodiazhnyi O.I., Kukhar V.P., Kolodiazhna A.O. Asymmetric catalysis as a method for the synthesis of chiral organophosphorus compounds. Tetrahedron: Asymmetry. 2014. Vol. 25 (12). P. 865–922. https://doi.org/10.1016/j.tetasy.2014.05.010 [Q2]

4. Kolodiazhna A.O., Kolodiazhnyi O.I. Catalytic Asymmetric Synthesis of C-Chiral Phosphonates. Symmetry. 2022. Vol. 14 (9). P. 1758. https://doi.org/10.3390/sym14091758 [Q2]

5. Kolodiazhna A.O., Kolodiazhnyi O.I. Chiral Organophosphorus Pharmaceuticals: Properties and Application. Symmetry (Basel). 2023. Vol. 15 (8). P. 1550. https://doi.org/10.3390/sym15081550

[Q2]

1. Myshko A.S., Mrug G.P., Bondarenko S.P., Kondratyuk K.M., Kobzar O.L., Buldenko V.M., Kozytskiy A.V., Vovk A.I., Frasinyuk M.S. Trapping of thermally generated ortho-and para-quinone methides by imidazoles and pyrazoles: a simple route to green synthesis of benzopyrone-azole hybrids and their evaluation as α-glucosidase inhibitors. RSC advances. 2024. Vol. 14 (38). P.  27809–27815. https://doi.org/10.1039/D4RA05230G [Q2]

2. Bondarenko S.P., Frasinyuk M.S. Chromone Alkaloids: Structural Features, Distribution in Nature, and Biological Activity. Chem Nat Compd. 2019. Vol. 55. P. 201–234. https://doi.org/10.1007/s10600-019-02656-0 [Q3]

3. Popova A.V., Bondarenko S.P., Frasinyuk M.S. Aurones: Synthesis and Properties. Chem Heterocycl Comp. 2019. Vol. 55. P. 285–299. https://doi.org/10.1007/s10593-019-02457-x [Q3]

4. Kobzar O.L., Tatarchuk A.V., Mrug G.P., Bondarenko S.P., Demydchuk B.A., Frasinyuk M.S., Vovk A.I. Carboxylated chalcones and related flavonoids as inhibitors of xanthine oxidase. Med Chem Res. 2023. Vol. 32. P. 1804–1815. https://doi.org/10.1007/s00044-023-03109-8 [Q3]

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