V.P. Kukhar Institute
of Bioorganic
chemistry and
Petrochemistry
NAS of Ukraine

Research areas, practical focus of work

• Research of approaches to synthesise potential biologically active substances based on structural analogues of natural compounds.
• Development of preparative methods for introducing pharmacophore groups into the appropriate positions of cyclic systems to enhance biological activity.
• Determination of the influence of structural features of the obtained compounds on biological activity.

Main scientific and practical achievements of the Department

Scientists of the Department

Lyubov Muzychka, Candidate of Chemical Sciences, Senior Research Fellow, Senior Researcher

https://www.scopus.com/authid/detail.uri?authorId=6505859851

https://orcid.org/0000-0001-5220-6965

Yevhenii Verves, Candidate of Chemical Sciences, Junior Research Fellow

https://www.scopus.com/authid/detail.uri?authorId=35249546100

Iryna Yaremchuk, Candidate of Chemical Sciences, Junior Research Fellow

https://www.scopus.com/authid/detail.uri?authorId=54920266600

Olexandr Kucher, Candidate of Chemical Sciences, Junior Research Fellow

https://www.scopus.com/authid/detail.uri?authorId=56076410800

https://orcid.org/0000-0002-3591-1600

Igor Biletskii, 1 Category Engineer

https://www.scopus.com/authid/detail.uri?authorId=57194545693

The most important publications of the Department researchers

1. Muzychka L., Muzychka O., Smolii O. Synthesis and Acetylcholinesterase Inhibitory Activity of Novel Trilaciclib Analogs. Chemistry & Biodiversity. 2025. 24(2). e202401874.  https://doi.org/10.1002/cbdv.202401874

2. Muzychka L., Hodyna D., Metelytsia L., Smolii O. Nature-Inspired Novel Quaternary Ammonium Compounds: Synthesis, Antibacterial and Antibiofilm Activity. ChemMedChem. 2025. 20(5). e202400807. https://doi.org/10.1002/cmdc.202400807

3. Muzychka L.V., Humeniuk N.I., Boiko I.O., Vrynchanu N.O., Smolii O.B. Synthesis and antibiofilm activity of novel 1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]pyrimidine-2-carboxamides. Biopolymers & Cell. 40(1). P. 68-80. http://dx.doi.org/10.7124/bc.000AAB

4. Dubina T.F., Kosarevych A.V., Kucher O.V., Sosunovych B.S., Smolii O.B., Vashchenko B.V., Grygorenko O.O. Synthesis and reactions of novel imidazo[4,5-b]pyridine building blocks. Chemistry of Heterocycllic Compounds. 60. P. 175-182. https://doi.org/10.1007/s10593-024-03315-1

5. Muzychka L.V., Humeniuk N.I., Boiko I.O., Vrynchanu N.O., Smolii O.B. Synthesis and in vitro evaluation antibacterial and antibiofilm activities of novel triphenylphosphonium-functionalized substituted pyrimidines Chemical Biology & Drug Design 103 (2). e14483 https://doi.org/10.1111/cbdd.14483

6. Muzychka L., Boiko I., Vrynchanu N., Smolii O. Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues. Current Chemistry Lett 2024. 13(2). P. 335-342. 10.5267/j.ccl.2023.11.005

7. Muzychka L.V., Verves E.V., Yaremchuk I.O., Zinchenko A.M., Shishkina S.V., Semenyuta I.V., Hodyna D.M., Metelytsia L.O., Kovalishyn V., Smoli O.B. Synthesis, QSAR modeling, and molecular docking of novel fused 7-deazaxanthine derivatives as adenosine A2A receptor antagonists. Chemical Biology and Drug Design. Vol. 100. P. 1025-1032.  https://doi.org/10.1111/cbdd.13975

8. Liubov Muzychka, Alona Voronkina, Valentine Kovalchuk,Oleg B Smolii, Marcin Wysokowski, Iaroslav Petrenko, Diaa T A Youssef, Irina Ehrlich, Hermann Ehrlich Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents. Appl Phys A Mater Sci Process. Vol.127, №1. P. 15. https://doi.org/10.1007/s00339-020-04167-0

9. Björn Binnewerg, Mario Schubert, Alona Voronkina, Liubov Muzychka, Marcin Wysokowski, Iaroslav Petrenko, Mirko Djurović, Valentine Kovalchuk, Mikhail Tsurkan, Oleg B. Smolii Marine biomaterials: Biomimetic and pharmacological potential of cultivated Aplysina aerophoba marine demosponge Materials Science Engineering C. 2020. Р. 110566. https://doi.org/10.1016/j.msec.2019.110566

10. Liubov V. Muzychka, Iryna O. Yaremchuk, Evgenii V. Verves, Oleg B. Smolii Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene. Chemistry of Heterocyclic Compounds. 2019. 55(4-5).397-400. https://doi.org/10.1007/s10593-019-02471-z

11. Zinchenko A.M., Muzychka L. V., Kucher O. V., Sadkova I. V., Mykhailiuk P., Smolii O. B. One-pot synthesis of 6-aminopyrido[2,3-d]pyrimidin-7-ones. European Journal of Organic Chemistry. 2018(46). P. 6519–6523. https://doi.org/10.1002/ejoc.201801204

12. Yaremchuk I.O., Muzychka L.V., Smolii O.B., Kucher O.V., Shishkina S.V. Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives. Tetrahedron Letters. 59. P. 442–444. https://doi.org/10.1016/j.tetlet.2017.12.065

Scientific and scientific-technical collaboration

• Department оf Biomineralogy & Extreme Biomimetics, Technical University Bergakademie Freiberg, Germany
• Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
• State Institution ‘Institute of Pharmacology and Toxicology’ of the National Academy of Medical Sciences of Ukraine
• National Technical University of Ukraine ‘Igor Sikorsky Kyiv Polytechnic Institute’

Department employees (2025) – O.V. Kucher, O.B. Smolii, E.V. Verves, L.V. Muzychka, I.I. Biletsky (from left to right).

Department employees (2017) – A. P. Gaevskyi, E. V. Verves, O. V. Kucher, L. V. Muzychka, O. B. Smoliy, G. M. Zinchenko, I. O. Yaremchuk, I. I. Biletskyi (from left to right).

Department employees (2017) – I.I. Biletsky, O.V. Kucher, L.V. Muzychka, O.B. Smolii, E.V. Verves, G.M. Zinchenko (from left to right).