Керівник: Михайло Сергійович Фрасинюк, кандидат хімічних наук
Публікації:
1. M. S. Frasinyuk, G. P. Mrug, S. P. Bondarenko, V. M. Sviripa, W. Zhang, X. Cai, M. V. Fiandalo, J. L. Mohler, C. Liu, D. S. Watt, Application of Mannich Bases to the Synthesis of Hydroxymethylated Isoflavonoids As Potential Antineoplastic Agents, Org. Biomol. Chem., 2015, 13 (46), 12292-11301. http://dx.doi.org/10.1039/C5OB01828E
2. М. С. Фрасинюк, Особливості амінометилювання похідних ескулетину, Ukr. Вioorg. Acta, 2015, 13 (1), 3 – 8.
3. M. S. Frasinyuk, S. P. Bondarenko, V. M. Sviripa, R. Burikhanov, V. M. Rangnekar, C. Liu, D. S. Watt, Development of 6H-Chromeno[3,4-c]pyrido[3′,2′:4,5]thieno[2,3-e]pyridazin-6-ones as Par-4 Secretagogues, Tetrahedron Lett., 2015, 56, 23, 3382 – 3384. http://dx.doi.org/10.1016/j.tetlet.2015.01.028
4. S. P. Bondarenko, М. S. Frasinyuk, V. P. Khilya, Synthesis of aloperine-containing Mannich bases of isoflavones, Chem. Nat. Compd., 2014, 51 (4), 643 – 645. http://dx.doi.org/10.1007/s10600-015-1375-8
5. T. V. Shokol, N. V. Gorbulenko, M. S. Frasinyuk, V. P. Khilya, Synthesis of 6-(3-Pyrazolyl)-4-Methylumbelliferone Derivatives Substituted on the Pyrazole Ring, Chem. Nat. Compd., 2014, 51 (4), 630 – 633. http://dx.doi.org/10.1007/s10600-015-1371-z
6. M. S. Frasinyuk, S. P. Bondarenko, V. P. Khilya, C. Liu, D. S. Watt, V. M. Sviripa, Synthesis and Tautomerization of Hydroxylated Isoflavones Bearing Heterocyclic Hemi-Aminals, Org. Biomol. Chem., 2015, 13 (4), 1053-1067. http://dx.doi.org/10.1039/c4ob02137a
7. Патент №105959, Україна, МПК (2014.01) С07D311/36, A61/K 31/00, C07D 295/04. 7-[2-(4-Етилпіперазин-1-іл)етокси]-2-метил-3-(4-хлорофеніл)-4Н-хромен-4-он та його застосування / І. С. Безверха, С. П. Бондаренко, М. У. Заїка, Т. М. Пантелеймонова, М. С. Фрасинюк, В. П. Хиля, Л. Б. Шарабура; патентовласник ДУ “Інститут геронтології ім. Д. Ф. Чеботарьова НАМНУ” – заявка № а20123435; заявл. 26.11.2012; опублік. 26.05.2014, Бюл. № 10.
8. G. P. Mrug, M. S. Frasinyuk, S. P. Bondarenko, V. S. Brovarets, V. P. Khilya, Aminomethylation of isoflavones with cyclic amino alcohols, Ukr. Вioorg. Acta, 2014, 12 (2), 10 – 14. http://www.bioorganica.org.ua/UBAdenovo/vol_12_2.htm
9. G. P. Mrug, M. S. Frasinyuk, V. P. Khilya, Synthesis of 8-hydroxymethyl and 8-alkoxymethyl 7-hydroxyisoflavone derivatives, Ukr. Вioorg. Acta, 2014, 12 (1), 24 – 28. http://www.bioorganica.org.ua/UBAdenovo/vol_12_1.htm
10. M. S. Frasinyuk, Synthesis and aminomethylation of 3-substituted 6-hydroxy-1,2-benzisoxazoles, Chem. Heterocycl. Compd., 2014, 50 (11), 1616-1623. http://dx.doi.org/10.1007/s10593-014-1631-z
11. S. P. Bondarenko, М. S. Frasinyuk, V. I. Vinogradova, V. P. Khilya, Synthesis of 4-aryl-3-[2-hydroxy-4-(2-cytisin-12-ylethoxy)phenyl]pyrazoles, Chem. Nat. Compd., 2014, 50 (5), 889-891. http://dx.doi.org/10.1007/s10600-014-1107-5
12. M. S. Frasinyuk, S. Kwiatkowski, J. M. Wagner, T. J. Evans, R. W. Reed, K. V. Korotkov, D. S. Watt, Pentapeptide Boronic Acid Inhibitor of Mycobacterium tuberculosis MycP1 Protease, Bioorg. Med. Chem. Lett., 2014, 24 (15), 3546-3548. http://dx.doi.org/10.1016/j.bmcl.2014.05.056
13. А. Hamza, J. M. Wagner, T. J. Evans, M. S. Frasinyuk, S. Kwiatkowski, C.-G. Zhan, D. S. Watt, K. V. Korotkov, Novel Mycosin Protease MycP1 Inhibitors Identified by Virtual Screening and 4D Fingerprints, J. Chem. Inf. Model., 2014, 54 (4), 1166 – 1173. http://dx.doi.org/10.1021/ci500025r
14. M. S. Frasinyuk, S. P. Bondarenko, N. V. Gorbulenko, A. V. Turov, V. P. Khilya, Cyclic carboxylic anhydrides as new reagents for formation of chromone ring, J. Heterocycl. Chem., 2014, 51, 768 – 774. http://dx.doi.org/10.1002/jhet.1721
15. M. S. Frasinyuk, G. P. Mrug, S. P. Bondarenko, V. P. Khilya, V. S. Brovarets, Antitumor activity of flavonoid Mannich bases, Ukrainica Bioorganica Acta, 2013, 11, 2, 3-7 (Ukr).http://www.bioorganica.org.ua/UBAdenovo/vol_11_2.htm
16. S. P. Bondarenko, M. S. Frasinyuk, Synhsis of aminomethyl derivatives of chrysin, Chem. Nat. Compd., 2013, 49, 841 – 844. http://dx.doi.org/10.1007/s10600-013-0760-4
17. S. P. Bondarenko, O. N. Miroshnikov, M. S. Frasinyuk, V. P. Khilya, Synthesis of 4-aryl-5-[2-hydroxy-4-?-(N,N-dialkylamino)ethoxyphenyl]isoxazoles, Chem. Nat. Compd., 2013, 49, 826 – 829. http://doi.org/10.1007/s10600-013-0757-z
18. G. P. Mrug, S. P. Bondarenko, V. P. Khilya, M. S. Frasinyuk, Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones, Chem. Nat. Compd., 2013, 49, 235 – 241. http://dx.doi.org/10.1007/s10600-013-0570-8
19. S. P. Bondarenko, М. S. Frasinyuk, V. I. Vinogradova, V. P. Khilya, Synthesis of Cytisine Derivatives of Flavonoids. 3. Synthesis of 7-[2-(cytisin-12-yl)ethoxy]isoflavones. Chem. Nat. Compd., 2012, 48, 970 – 973. http://dx.doi.org/10.1007/s10600-013-0441-3
20. S. P. Bondarenko, М. S. Frasinyuk, V. P. Khilya, T. M. Panteleymonova, I. S. Bezverkha, Synthesis and antioxidant activity of 6- and 7-hydroxy-3-arylcoumarins, Ukrainica Bioorganica Acta, 2012, 10, 42 – 47. http://www.bioorganica.org.ua/UBAdenovo/vol_10_1.htm
21. S. V. Gorelov, S. P. Bondarenko, М. S. Frasinyuk, Synthesis and Properties of 4-(3-Aminothieno[2,3-b]pyridin-2-yl)coumarins, Chem. Heterocycl. Compd., 2012, 48, 955-962. http://dx.doi.org/10.1007/s10593-012-1083-2
22. M. S. Frasinyuk, G. P. Mrug, O. D. Fedoryak, S. P. Bondarenko, Synthesis of aminoacyl derivatives of formononetin and cladrin, Chem. Nat. Compd., 2012, 48, 570-573. http://dx.doi.org/10.1007/s10600-012-0313-2.
23. S. P. Bondarenko, М. S. Frasinyuk, A. I. Galayev, V. I. Vinogradova, New flavonoid-contain derivatives of lupinine. Chem. Nat. Compd., 2012, 48, 234-237. http://dx.doi.org/10.1007/s10600-012-0212-6
24. М. S. Frasinyuk, S. P. Bondarenko, V. P. Khilya, Chemistry of 3-Hetarylcoumarins. 3. Synthesis and Aminomethylation of 7′-Hydroxy-3,4′-bicoumarins. Chem. Heterocycl. Compd., 2012, 48, 422- 426. http://dx.doi.org/10.1007/s10593-012-1009-z
25. S. P. Bondarenko, М. S. Frasinyuk, V. P. Khilya, Synthesis of Aminomethyl Derivatives of Sophoricoside. Chem. Nat. Compd., 2012, 48, 26-29. http://dx.doi.org/10.1007/s10600-012-0151-2
26. S. P. Bondarenko, М. S. Frasinyuk, V. I. Vinogradova, V. P. Khilya, Synthesis of Cytisine Derivatives of Flavonoids. 2. Aminomethylation of 7-hydroxyisoflavones. Chem. Nat. Compd., 2011, 47, 604-607. http://dx.doi.org/10.1007/s10600-011-0006-2
27. М. S. Frasinyuk, S. P. Bondarenko, O.V. Shablykina, V. P. Khilya, Formylation of 5-Hydroxybenzofuran Derivatives and Synthesis of Furo[3,2-f]coumarins based them. Chem. Heterocycl. Compd., 2011, 47, 1155- 1163. http://dx.doi.org/10.1007/s10593-011-0886-x
28. S. P. Bondarenko, М. S. Frasinyuk, V. I. Vinogradova, V. P. Khilya, Synthesis of flavonoid derivatives of cytisine. 1. Aminomethylation of 7-hydroxy-3-arylcoumarins. Chem. Nat. Compd., 2010, 46, 771-773. http://dx.doi.org/10.1007/s10600-010-9737-8
29. S. P. Bondarenko, М. S. Frasinyuk, V. P. Khilya, Aminomethylation of 3-Aryl -7-hydroxycoumarins. Chem. Heterocycl. Compd., 2010, 46, 529-535. http://dx.doi.org/10.1007/s10593-010-0541-y
30. S. P. Bondarenko, М. S. Frasinyuk, V. P. Khilya, Features of Aminomethylation of 7-Hydroxy-4′-Fluoroisoflavones with Primary Amines, Chem. Heterocycl. Compd., 2010, 46, 146-150. http://dx.doi.org/10.1007/s10593-010-0485-2
31. Waszkowska K., Krupka A., Smokal V., Kharchenko O., Migalska-Zalas A., Frasinyuk M., Wielgosz R., Andrushchak A., Sahraoui B. C Correlation between Nonlinear Optical Effects and Structural Features of Aurone-Based Methacrylic Polymeric Thin Films. Materials 2022, 15(17), 6076; https://doi.org/10.3390/ma15176076.
